09.2021:

The µOrgano Lab is hiring!

Are you a driven, innovative, collaborative and curious scientist looking for a challenge? Our group is looking to fill multiple open positions, for a postdoctoral and master's thesis candidates. Follow this link for more information .

07.2021:

µOrgano Lab PhD student Tengku Ibrahim Maulana wins Best Junior Presentation Award

Congratulations to Ibra for winning the Best Junior Presentation Award at the virtual EUROoCS 2021 conference. His talk, titled 'Breast-cancer-on-chips recapitulating tumor micro-environment interaction applicable for CAR-T cell testing', was one of the nearly 40 talks presented during the two-day conference.

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07.2021:

Peter Loskill appointed as new chair of EUROoCS

It has been nearly three years since the launch of the European Organ-on-Chip Society (EUROoCS). After serving as Vice-Chair for the last years, Peter Loskill has now been appointed as the new chair of EUROoCS and will give his best to support the success story of this emerging society. The overall goals of EUROoCS include:

Creating a road-map for OoC technology
Building a network of academia, research institutes, industry and regulatory bodies
Raising awareness and building an ecosystem for OoC technologies

05.2021:

Rapid and robust chip fabrication with thermoplastic elastomers and hybrid materials

We present a rapid and scalable fabrication method for microfluidic systems involving thermoplastic elastomer and polycarbonate hybrid materials. This hybrid material can be effectively bonded to others, resulting in a well-bonded, low absorbing alternative to PDMS. The full paper can be accessed using this link.

04.2021:

Membrane integration into PDMS-free microfluidic platforms for organ-on-chip and analytical chemistry applications

Membranes play a critical key role in many microfluidic systems, enabling diverse applications in different research fields. Our review article nicely displays an introduction into microfluidic systems applying membrane technology for analytical and organ-on-chip systems. In most cases, polydimethylsiloxane (PDMS) is used to build microfluidic chips. This is, however, accompanied by a number of limitations. For this reason, the review focuses on the integration of membranes into PDMS-free systems. The review is published in Lab on a Chip.

04.2021:

The µOrgano-Lab is moving!

After many great years in Stuttgart, we are excited to start a new chapter. From May 2021 on, the µOrgano-Lab will form together with the 3R Center Tübingen a new European hub for Organ-on-Chip research at the University of Tübingen and the Natural and Medical Sciences Institute (NMI) supported by the state of Baden-Württemberg.

03.2021:

Organ-on-a-Disc technology featured on a podcast

Stefan Schneider was interviewed by the SLAS podcast following his very successful presentation at the SLAS conference in March. He shares his journey through the PhD and discusses the potential of Organ-on-a-Disc technology in the automation of Organ-on-chip research. Check out the link here.

03.2021:

Organ-on-Chips in immuno-oncology research

Immunocompetent Cancer-on-Chip (iCoC) models are powerful tools to better understand the pathogenesis of cancer and to develop novel (immuno-)therapies. In the framework of the IMI2 project imSAVAR we reviewed the current state, the opportunities and the future applications of iCoCs. Click here to access the paper.

03.2021:

Obesity and infections in the pulmonary tract

In this review, we summarized the main impacts of obesity on the pulmonary tract caused by obesity. In light of the global pandemic, we also discussed the pathogenesis of bacterial and viral infections in connection to obesity, and the current in vitro and in vivo models being used to study obesity-related mechanisms. For more information, click here.

02.2021:

Moving towards more physiological, less absorbing OoCs

Our latest publication in the ACS Biomaterials Science and Engineering Journal introduces a minimally absorbing thermoplastic chip with an integrated electrospun membrane. This chip sustained a coculture of human endothelial cells and retinal pigment epithelial cells for 7 days under perfusion. Follow this link for more details.

02.2021:

The MicroOrgano Lab will CRACK IT

We were recently awarded Phase I funding for the CRACK IT challenge to create a human in vitro T-cell dependent antibody response assay (TDAR) using OoC technology. Our TDAR assay could enable the assessment of preclinical immunomodulatory therapeutics and reduce testing in non-human primates. This will contribute towards 3Rs advances in preclinical sciences and safety assessment across the bioscience sector.

Click here for more information about the press release and here for the current status of the challenge.

Sponsors: Bayer AG, GSK, Merck Healthcare KGaA and Novartis Pharma AG

02.2021:

Towards better immunotherapies

New project funded by Wellcome Leap. The µOrgano Lab was selected as "performers" for the "Human Organs, Physiology, and Engineering" (HOPE)-Program (https://wellcomeleap.org/hope/). Together with partners from NMI, Miltenyi Biotec B.V. & Co. KG and LaVision BioTec, we will be working on a high-content multi-organ-chip that recapitulates immune-tumor interaction.

01.2021:

µOrgano Lab PhD student Stefan Schneider wins Tony B. Academic Award:

Congratulations to Stefan for winning the prestigious Tony B. Academic Award at the virtual SLAS2021 conference. He will present his work on “Organ-on-a-Disc: a Platform Technology for the Automated and Parallelized Generation and Culture of Microphysiological 3D Tissues based on Centrifugal Forces” on January 25,2021.

12.2020:

Explaining the Organ-on-Chip technology to kids and teenagers:

Interested to teach your kids and teenagers about the concepts and potentials of the OoC technology? We have published an introductory article especially tailored for a young audience in "Frontiers for Young Minds" (https://kids.frontiersin.org/article/10.3389/frym.2020.544390).

10.2020:

Our Organ-on-a-disc paper was recently published:

Practical applications of Organ-on-Chip have been limited by its reliance on manual handling and the subsequent low-throughput.

To overcome these limitations and achieve better throughput, we developed the Organ-on-a-disc, or Organ-Disc, technology by combining the concepts of Organ-on-a-chip with centrifugal microfluidics. Check out our featured publication in APL Bioengineering (https://doi.org/10.1063/5.0019766) and the API Scilight (https://doi.org/10.1063/10.0002249).

02.09.2020:

Mini organs with big potential:

Our research was recently featured in the website "Gesundheitsindustrie-BW" in german, highlighting the importance and need for organ on chip research to reduce and replace animal testing for safety and efficacy testing. This website platform provides reports on developments in the healthcare field in Baden Württemberg.

08.-09.07.2020:

First virtual EUROoCs 2020 conference:

While it would have been great to visit Sweden, the virtual EUROoCs conference was a great success, and we were excited to participate with two selected talks from Johanna Chuchuy and Oliver Schneider, and several posters by the lab members. A big congratulations to Oliver Schneider for winning the Young Investigator award, and to Julia Rogal and Katharina Schluender for honorable mentions in the Poster Award category. We look forward to EUROoCs 2021, scheduled to be held in Uppsala.

06.2020:

BIOspektrum article about the Retina-on-Chip:

Check out our new BIOspektrum article about the Retina-on-Chip in layman’s term for the general (German-speaking) public: https://doi.org/10.1007/s12268-020-1413-3.

06.2020:

µOrgano Lab vs. Corona:

The µOrgano Team is contributing to the fight against SARS-CoV-2 by trying to repurpose drugs in a SARS-CoV-2 infection model in an immunocompetent lung-on-a-chip platform and by developing a reusable powered air-purifying respirator (PAPR) for infection control of medical personnel. Learn more at https://www.igb.fraunhofer.de/en/reference-projects/C19.html and https://www.igb.fraunhofer.de/en/reference-projects/PAPR.html.

05.2020:

Interested in learning more about Organoids and Organ-on-Chip?!

Informative article for all German speakers in the "Laborjournal" including interviews with Peter and our collaborators André Koch and Stefan Liebau http://www.laborjournal-archiv.de/epaper/LJ_20_05/32/index.html.

20.04.2020:

Our new adipose chip paper is now published in the open access Nature journal "Scientific Reports"

Have a look at the paper here.

01.2020:

Postdoc position available in the µOrgano-Lab!

Do you have a Ph.D. and an interest in developing in vitro models for the immune safety assessment of biologicals? Here is an exciting postdoctoral opportunity to work on developing an organ-on-a-chip platform to assess immune safety in the framework of the IMI imSAVAR project in collaboration with academic and industry partners. Postdoctoral candidates with biomedical engineering, biophysics and similar expertise are encouraged to apply. For more details about the offer, please visit this link.

01.2020:

Peter Loskill on the 2020 LushPrize Shortlist

Dr. Peter Loskill has been shortlisted to receive the Lush Prize 2020 in the "Young Researcher" category. The Lush Prize is aimed at research focused on consumer product safety and toxicity testing without the use of animals. For more details about the award, clink on this link.

01.2020:

New article about organ-on-chip in heise technology review

Check out the new article titled „Mehr Mensch fürs Labor” on organoids and organ-on-chip in the January edition of “Heise Technology Review” featuring an interview with Dr. Peter Loskill.

04.11.2019:

New collaboration-partner Emulate Bio

We have started a strategic partnership with the buzzing startup Emulate Bio and are looking forward to bring the Organ-on-Chip technology together to the next level and enable it to deliver on its promises as well as to accelerate adoption of the technology.

Check also the following link.

27.08.2019:

Our retina-on-a-chip paper was recently accepted in the journal "eLife": https://elifesciences.org/articles/46188

For more information, read the following article.

11.-16.08.2019:

Our post-doc Madalena won Eurotox travel grant

Congratulations to our postdoctoral candidate Dr. Madalena Cipriano for receiving the Eurotox travel fellowship to attend the Cellular and Molecular Mechanisms of Toxicity GRC this year. Says Madalena, "Participating in the Gordon Research Conference Cellular and Molecular Mechanisms of Toxicology (CMMT) and being awarded with the EUROTOX fellowship allowed me to further develop myself as a Toxicologist and grow my network beyond the European sphere in an open and integrating environment. The GRC is the perfect place for the communication of scientific knowledge and promotes an accessible atmosphere for discussion. The key for this openness are the small number of participants, long participative poster sessions and excellent scientific content spread throughout emerging topics in toxicology. During the GRC, I had plenty of opportunities to interact with top scientists and trainees from academia, governmental agencies and industry to exchange ideas, establish collaborations and find mentors while going for swimming, hiking or playing volleyball in the wonderful venue of Proctor Academy. The GRC was the most unique conference I attended. I definitely encourage European scientists to experience GRC and I look forward coming back for the next CMMT in 2 years."

03. Juli 2019:

European Organ-on-Chip Society open for active membership - The founding phase is complete

The European Organ-on-Chip Society (EUROoCS) is now welcoming members to join. The annual conference, held this year in Graz (Austria), saw launch of the community website and the start of its availability as an information resource, see here.

02.-03. Juli 2019:

1st Annual Conference of the European Organ-on-Chip Society

Jun.-Prof. Dr. Peter Loskill is a founding member and vice chair of the EUROoCS network, which is committed to promoting the organ-on-chip technology internationally. On July 2 and 3, 2019, the first EUROoCs annual conference took place at the University of Technology in Graz, bringing together around 230 international scientists. The conference provided a platform for constructive discussion in this highly interdisciplinary and translational field, bringing together biologists and engineers, industry and academia.

For several colleagues of the IGB the attendance of the annual EUROoCS conference was very successful. Julia Rogal and Johanna Chuchuy were awarded with a prize over 250 € for their poster presentations »WAT-on-a-chip: Microphysiological systems integrating human white adipose tissue« and »Retina-on-a-Chip: Controlled illumination of a PDMS-free Retina-on-a-Chip for the proximity-culture of retinal organoids with pigment epithelial cells«, respectively. Their collegue, Oliver Schneider, was chosen by an international committee to receive the EUROoCS Travel Award, which subsidizes the travel expenses.

01. Juli 2019:

Kick-off of the MSCA-ITN EUROOC, the interdisciplinary training network for advancing Organ-on-a-chip technology in Europe coordinated by Jun.-Prof. Dr. Peter Loskill.

13. November 2018:

Launch of the European Organ-on-Chip Society (EUROoCS). The Society aims to encourage and develop Organ-on-Chip research towards a better health for everyone. Peter Loskill will serve as the vice-chair.

October 2018:

The current Issue 48 of attempto! the University of Tübingen Magazine features our lab with a very nice and comprehensive story.

07.09.2018:

Dr. Christopher Probst and Stefanie Fuchs received young scientists travel awards for the EUSAAT conference

13.07.2018:

Dr. Christopher Probst received an award from the Science2Start-competition

12.06.2018:

Interview of Stefan Schneider in the Journal "F.A.Z. Hochschulanzeiger"

Stefan Schneider: "Ich will an innovativen Lösungen arbeiten".

Click here to read the whole interview.

02.04.2018:

The website is Live!

You are here. So it exists.

Thanks to everyone in the lab for putting the information and images together. Special thanks to Johanna Chuchuy and Elena Rubiu for taking the lead.

Dr. Christopher Probst received a Keystone Symposia scholarship

Dr. Christopher Probst received a Keystone Symposia scholarship to attend the upcoming meeting on Organs- and Tissues-on-Chips, Apr 8 - Apr 12, 2018, in Big Sky Resort in Big Sky, Montana.

We are hosting the EUROoC in Stuttgart, May 24-25th 2018

The EUROoC meeting aims to attract leading international researchers for knowledge-sharing and networking with a clear focus on engineering perspectives of organ-on-chip and microphysiological systems. The meeting series would especially like to attract the participation of young and upcoming scientists with the ambition to become the natural meeting place for researchers in the organ-on-chip field in Europe.

The first EUROoC meeting calls for scientific contributions addressing the engineering challenges associated with organ-on-chip. The meeting will take place in Stuttgart, Germany, 24-25 May, 2018.